Research:

Genomic instability contributes to both the development and progression of cancer. – Mutations affecting the detection or repair of DNA damage can dramatically increase genome instability and therefore cancer susceptibility. A key question in cancer biology is how the cell detects and repairs DNA damage?

We are studying how the structure of the mammalian nucleus, including chromatin and the various nuclear domains, contributes to DNA damage surveillance, signaling and repair.

CURRENT RESEARCH THEMES:

1. The role of chromatin structure and nuclear subdomains in DNA repair
2. CRISPR Genome Engineering and Ethics of Gene Editing
3. Evolutionary Molecular Biology of Innate Immunity and the Cell Stress Response
4. Environmental Carcinogens and Cancer Risk – funded by the Canadian Cancer Society

Previous Funded Research Themes:

Xenotransplantation in zebrafish as a human tumour model

Mechanisms of Chemotherapy Resistance in breast, ovarian and prostate cancer

Super-Resolution and Live-Cell Imaging of Cancer Cells – SRRF On My System (SOMS) Blog

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Founder and Member of the Canadian Environmental Exposures in Cancer (CE2C) Network
FUNDING:
	Natural Sciences and Engineering Research Council of Canada