Our laboratory is interested in developmental neurobiology with an emphasis on intracellular signaling complexes underlying neuronal polarity. We utilize molecular and cellular approaches, combined with Mass Spectrometry based screens, to characterize protein complexes involved in establishing neuronal polarity and synapse development.
A second area of research focuses on the development of spinal cord circuits that control movement. In particular we are focusing on the development of the central pattern generator, an intrinsic spinal circuit that controls walking. We have developed a mouse model to identify important interneuronal populations that are involved in the establishment of these neuronal circuits. Collaborators include Dr. Robert Brownstone (UCL), Drs. Victor Rafuse and Ying Zhang, members of the Atlantic Mobility Action Project (AMAP) at Dalhousie University as well as Drs Roy Duncan and Stefan Krueger.
Our laboratory is currently located in the Life Science Research Institute.